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How should I take JARDIANCE?

Some MEDICINES MAY INTERACT with torsemide. What should I tell my doctor before using JARDIANCE? What is the treatment for idiopathic edema? Dose adjustments may be required; however, no specific guidelines have been suggested; contraindicated in patients with anuria.

Does torsemide interact with other medications

Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. In patients with decompensated congestive heart failure, hepatic and renal clearance are both reduced, probably because of hepatic congestion and decreased renal plasma flow, respectively. The total clearance of Torsemide is approximately 50% of that seen in healthy volunteers, and the plasma half-life and AUC are correspondingly increased. Because of reduced renal clearance, a smaller fraction of any given dose is delivered to the intraluminal site of action, so at any given dose there is less natriuresis in patients with heart failure than in normal subjects.

Before taking torsemide

HbA1c, treatment, renal function, and background medication. Excessive diuresis may cause potentially symptomatic dehydration, blood volume reduction and hypotension and worsening renal function, including acute renal failure particularly in salt-depleted patients or those taking renin-angiotensin aldosterone inhibitors. There are no data regarding the presence of Torsemide in human milk or the effects of Torsemide on the breastfed child. Diuretics can suppress lactation. Development: Oral contraceptive use and the risk of breast cancer. L during the subsequent year. In long-term studies in diabetics, mean fasting glucose values were not significantly changed from baseline.

General information about torsemide

DEMADEX is not necessary. Glucose tolerance may be decreased. To prevent hypokalemia and metabolic alkalosis, use an aldosterone antagonist or potassium-sparing drug with Torsemide in patients with hepatic disease. Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.



About torsemide

Store at room temperature away from light and moisture. not store in the bathroom. Keep all away from children and pets. AUC did not result in adverse developmental effects. The most common reasons for discontinuation of therapy with torsemide were in descending order of frequency dizziness, headache, nausea, weakness, vomiting, hyperglycemia, excessive urination, hyperuricemia, hypokalemia, excessive thirst, hypovolemia, impotence, esophageal hemorrhage, and dyspepsia. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your or local waste disposal company. Torsemide tablets are indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including the class to which this drug principally belongs. There are no controlled trials demonstrating risk reduction with Torsemide. HW. The noncontraceptive health benefits from oral contraceptive use. Black. The mean age was 63 years and approximately 72% were male. St. John's wort, your pills may not work as well. CYP2C9 inhibitor or inducer. DAY AT THE SAME TIME.



HbA1c greater than or equal to 7%

DEMADEX in patients with hepatic disease. How should I take JARDIANCE? You can browse Drugs A-Z for a specific prescription or over-the-counter drug or look up drugs based on your specific condition. This information is for educational purposes only, and not meant to provide medical advice, treatment, or diagnosis. Remember to always consult your physician or health care provider before starting, stopping, or altering a treatment or health care regimen. UGT1A3, UGT1A8, UGT1A9, and UGT2B7. Sunday start or a Day 1 start. It is unknown if this drug passes into milk. Consult your doctor before -feeding. WOMAN-YEARS BY AGE, SMOKING STATUS, AND ORAL CONTRACEPTIVE USE. BMI and duration of disease.



Side effects of torsemide

Concomitant use with Torsemide may increase risk of hypokalemia. To report SUSPECTED ADVERSE REACTIONS, contact TEVA USA, PHARMACOVIGILANCE at tel: 1-866-832-8537or drug. Do not skip pills even if you do not have sex very often. SHBG in female acne patients treated with two different oral contraceptives. Doses higher than 200 mg have not been adequately studied. Drug Interactions In patients with essential hypertension, torsemide has been administered together with beta-blockers, ACE inhibitors, and calcium-channel blockers. In patients with congestive heart failure, torsemide has been administered together with digitalis glycosides, ACE inhibitors, and organic nitrates. None of these combined uses was associated with new or unexpected adverse events. Transnational Research Group on Oral Contraceptives and Health of Young Women. Evaluating the health risks and benefits of birth control methods. M3 2%, and metabolite M5 34%. Torsemide can cause potentially symptomatic hypokalemia, hyponatremia, hypomagnesemia, hypocalcemia, and hypochloremic alkalosis. Treatment with Torsemide can cause an increase in blood glucose levels and hyperglycemia. Asymptomatic hyperuricemia can occur and gout may rarely be precipitated. Monitor serum electrolytes and blood glucose periodically. Torsemide may also be used for purposes not listed in this medication guide. Your doctor will want to monitor your condition while you're taking this medicine. Be sure to keep all appointments with your doctor's office and laboratory. This drug may make you dizzy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit beverages. It is important to continue taking your pills on schedule. JARDIANCE as a fixed dose combination tablet.



NDC 0597-0152-37 institutional pack

Store at room temperature away from moisture and heat. Torsemide, USP is a white to off-white crystalline powder. Each Torsemide Tablet for oral administration contains 5 mg, 10 mg, 20 mg or 100 mg of Torsemide, USP. In addition, each tablet contains the following inactive ingredients: colloidal silicon dioxide, corn starch, lactose monohydrate, magnesium stearate and sodium starch glycolate. Most renal clearance of Torsemide occurs via active secretion of the drug by the proximal tubules into tubular urine. Keep taking 1 pill each day until the pack is empty. Torsemide is contraindicated in patients who are anuric. The opinions expressed in WebMD Communities are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. Communities are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Ory HW. Mortality associated with fertility and fertility control: 1983. Obstet Gynecol 1987; 7029-32. Organon, Oss, The Netherlands For patent information: www. Appropriate diagnostic and therapeutic measures should be undertaken immediately. Alcohol may worsen certain side effects of torsemide. Avoid drinking alcohol while taking this medicine. In the placebo-controlled hypertension studies excessive urination was dose related; 1% of patients receiving placebo, 4% of those treated with 5 mg of daily Torsemide, and 15% of those treated with 10 mg. Excessive urination was generally not reported as an adverse event among patients who received Torsemide for cardiac, renal, or hepatic failure. The other loop diuretic, when administered during the first weeks of life, has also been reported to increase the risk of persistent patent ductus arteriosus. The use of Torsemide in such patients has not been studied. Cimetidine: The pharmacokinetic profile and diuretic activity of Torsemide are not altered by cimetidine.



What is torsemide

IV and oral: 20 mg once a day; if diuresis remains inadequate, titrate upward by approximately doubling the dose until desired response is achieved; single doses higher than 200 mg have not been adequately studied. The pharmacokinetic profile and diuretic activity of torsemide are not altered by cimetidine or spironolactone. Coadministration of digoxin is reported to increase the area under the curve for torsemide by 50%, but dose adjustment of torsemide is not necessary. Concomitant use of torsemide and cholestyramine has not been studied in humans but, in a study in animals, coadministration of cholestyramine decreased the absorption of orally administered torsemide. If torsemide and cholestyramine are used concomitantly, simultaneous administration is not recommended. Coadministration of probenecid reduces secretion of torsemide into the proximal tubule and thereby decreases the diuretic activity of torsemide. Other diuretics are known to reduce the renal clearance of lithium, inducing a high risk of lithium toxicity, so coadministration of lithium and diuretics should be undertaken with great caution, if at all. Coadministration of lithium and torsemide has not been studied. Other diuretics have been reported to increase the ototoxic potential of aminoglycoside antibiotics and of ethacrynic acid, especially in the presence of impaired renal function. These potential interactions with torsemide have not been studied. Why do people with kidney disease have pitting edema? Torsemide clearance and increase Torsemide plasma concentrations. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. What causes edema during pregnancy? HbA1c, treatment, renal function, and region. Tell you doctor or dentist that you take torsemide before you receive any medical or dental care, emergency care, or surgery. Check your blood pressure regularly while taking this medication. Learn how to monitor your own blood pressure at home, and share the results with your doctor. Why does a person with heart disease retain fluid?



This has led to in some cases

Every effort has been made to ensure that the information provided by on this page is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. The information on this page has been compiled for use by healthcare practitioners and consumers in the United States and therefore neither Everyday Health or its licensor warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Neither Everyday Health nor its licensors endorse drugs, diagnose patients or recommend therapy. Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Keep taking 1 pill every day until Sunday. The changes subsided with chronic therapy. The Food and Drug Administration FDA approved torsemide in 1993. It's manufactured as Demadex by Roche Pharmaceuticals. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Dizziness or headache may occur as your body adjusts to the medication. If either of these effects persist or worsen, tell your doctor or pharmacist promptly.



United States is 8 mg per day

There are no available data on use of Torsemide in pregnant women and the risk of major birth defects or miscarriage. Forman D, Vincent TJ, Doll R. Cancer of the liver and oral contraceptives. Torsemide tablets are indicated for the treatment of edema associated with heart failure, renal disease or hepatic disease. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN. How should I store JARDIANCE? JARDIANCE in combination with metformin. JARDIANCE 25 mg treated patients. Difference from placebo adjusted mean 97. If you miss a dose of torsemide, take it as soon as you remember. Symptoms may include confusion; dizziness; dizziness or lightheadedness when sitting up or standing; dry mouth; excessive urination followed by a decrease in the amount of urine; muscle cramps or weakness; rapid or irregular heartbeat. Monitor and treat as appropriate. Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. JARDIANCE 10 mg, 25 mg, and placebo was 45 IU, 48 IU, and 48 IU, respectively. In patients with essential hypertension, Torsemide has been shown in controlled studies to lower blood pressure when administered once a day at doses of 5 mg to 10 mg. The antihypertensive effect is near maximal after 4 to 6 weeks of treatment, but it may continue to increase for up to 12 weeks. Systolic and diastolic supine and standing blood pressures are all reduced. There is no significant orthostatic effect, and there is only a minimal peak-trough difference in blood pressure reduction. NDC 0597-0152-37 institutional pack.



Breast-Feeding in GENERAL PRECAUTIONS

The recommended initial dose is 5 mg or 10 mg oral Torsemide tablets once daily, administered together with an aldosterone antagonist or a potassium-sparing diuretic. If the diuretic response is inadequate, titrate upward by approximately doubling until the desired diuretic response is obtained. Doses higher than 40 mg have not been adequately studied in this population. White to off white, round, biconvex tablets, debossed with “PA” and “915” on one side and scored on the other side. Basics, Side Effects, Interactions, and Dosage tabs. The information within the Reviews and FAQ tabs is proprietary to Everyday Health. MACE if noninferiority was demonstrated. Tinnitus and hearing loss usually reversible have been observed with loop diuretics, including Torsemide. Higher than recommended doses, severe renal impairment, and hypoproteinemia, appear to increase the risk of ototoxicity. Torsemide may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use torsemide with caution. L during the subsequent year. JARDIANCE promptly and institute treatment. Taking too much torsemide can lead to serious water and mineral loss. Be sure to take this medicine exactly as your doctor prescribes. In Progesterone and Progestin. If you have any questions about torsemide, please talk with your doctor, pharmacist, or other health care provider. Report prolonged or to your doctor. Follow your doctor's instructions about the amount of fluids you can drink.



Reviews for torsemide

Each green tablet contains inert ingredients. If you miss pills you could get pregnant. Adapted from refs. 2 and 3 with the authors' permission. Pharmaceuticals Inc. Somerset, NJ 08873-4120. Ketoacidosis increased ketones in your blood or urine. Cholestyramine and colestipol can decrease the absorption of torsemide. If you are taking either of these drugs, separate the timing of each dose from torsemide by at least 2 hours. Mario Negri Institute for Pharmacological Research, Milan. Torsemide is contraindicated in patients with known hypersensitivity to Torsemide. Overdose symptoms may include severe forms of some of the side effects listed in this medication guide. What happens if I overdose Demadex? In controlled studies in the United States, Torsemide was administered to hypertensive patients at doses of 5 mg or 10 mg daily. Take this by as directed by your doctor, with or without food, usually once daily. It is best to avoid taking this medication within 4 hours of your to prevent having to get up to urinate.



Torsemide ingredients

Torsemide clearance and decrease plasma Torsemide concentrations. Monitor diuretic effect and blood pressure when used in combination with CYP2C9 inhibitor or inducer. Adjust Torsemide dose if necessary. JARDIANCE in patients with type 2 diabetes and renal impairment. The recommended initial dose is 20 mg oral Torsemide tablets once daily. If the diuretic response is inadequate, titrate upward by approximately doubling until the desired diuretic response is obtained. Doses higher than 200 mg have not been adequately studied. Concomitant use of Torsemide and cholestyramine has not been studied in humans but, in a study in animals, coadministration of cholestyramine decreased the absorption of orally administered Torsemide. If Torsemide and cholestyramine should be coadministered, administer Torsemide at least one hour before or 4 to 6 h after cholestyramine administration. What is idiopathic edema? If you are taking either of these drugs, separate the timing of each dose from torsemide by at least 2 hours. Oral contraceptives are highly effective. Torsemide is to be used only by the patient for whom it is prescribed. Do not share it with other people. THROW AWAY the pills you missed. On a body-weight basis, these doses are 27 to 96 times a human dose of 20 mg; on a body-surface-area basis, they are 5 to 8 times this dose. In the rat study, the high-dose female group demonstrated renal tubular injury, interstitial inflammation, and a statistically significant increase in renal adenomas and carcinomas. The tumor incidence in this group was, however, not much higher than the incidence sometimes seen in historical controls. Similar signs of chronic non-neoplastic renal injury have been reported in high-dose animal studies of other diuretics such as furosemide and hydrochlorothiazide. What kind of doctors treat edema? WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider.



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List of torsemide side effects


Torsemide consumer information

Be sure to tell your healthcare provider you're taking torsemide before having any type of surgery, including a dental procedure. However, liver cancers are extremely rare. Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure JNC. If you suspect an overdose, contact a poison control center or emergency room immediately. Also, if you're taking Questran take it four hours before, or one hour after, taking torsemide.

Highlights for torsemide

You can get in touch with a poison control center at 800-222-1222. Instruct patients to take JARDIANCE only as prescribed. Torsemide and 3% on placebo. In patients followed for 1 year, there was no progressive change in mean serum potassium levels. In patients with congestive heart failure, hepatic cirrhosis, or renal disease treated with Torsemide at doses higher than those studied in United States antihypertensive trials, hypokalemia was observed with greater frequency, in a dose-related manner. Neill CA, Gutberlet R. Maternal hormone therapy and congenital heart disease. This has led to in some cases.

DAY AT THE SAME TIME

Torsemide is not recommended for use in CHILDREN; safety and effectiveness have not been confirmed. Ketoacidosis may lead to death. Have your checked regularly while taking this medication. Learn how to monitor your own pressure at home, and share the results with your doctor. It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

What are the possible side effects of torsemide

Tell your doctor if you develop any new symptoms. Torsemide may cause dizziness, fainting, or drowsiness. Don't drive or perform activities that require alertness until you know how this medicine affects you. Layde and V. Beral, ref. Torsemide may make your skin more sensitive to sunlight. Avoid unnecessary sun exposure, sunlamps, and tanning booths. Wear sunscreen or protective clothing while outdoors. Spironolactone: In healthy subjects, coadministration of Torsemide was associated with significant reduction in the renal clearance of spironolactone, with corresponding increases in the AUC. However, the pharmacokinetic profile and diuretic activity of Torsemide are not altered by spironolactone.

It's not known whether the medicine passes into breast milk or could hurt a nursing baby. Talk to your doctor before taking this medicine if you're breastfeeding. Take torsemide by mouth with or without food. All medicines may cause side effects, but many people have no, or minor, side effects. JARDIANCE may cause harm to nursing infants. Torsemide is a substrate of CYP2C9.

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